Methylfolate and methyl-B12 cause anxiety and insomnia in slow-COMT people. See who should avoid them; check your own COMT from your 23andMe data.
4-Jul 2026â˘10 min read
Explore articles related to overmethylation from our genomic wellness library.
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Methylfolate and methyl-B12 cause anxiety and insomnia in slow-COMT people. See who should avoid them; check your own COMT from your 23andMe data.
L-methylfolate (5-MTHF) is folate in active form, bypassing a slow MTHFR enzyme. See which form and dose fit â and check your own MTHFR from your DNA.
Overmethylation symptomsâanxiety, insomnia, wired feelingâfrom methyl donors plus slow COMT/MTHFR. Check your own risk from your 23andMe/AncestryDNA data.
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